Multi-site longitudinal, epidemiologic study designed to examine the health of women during their middle years. Examines the physical, biological, psychological, and social changes during this transitional period. The goal is to help learn how mid-life experiences affect health and quality of life during aging. Includes questions about doctor visits, medical conditions, medications, treatments, medical procedures, relationships, smoking, and menopause related information such as age at pre-, peri- and post-menopause, self-attitudes, feelings, and common physical problems associated with menopause. Also included are background characteristics (age, race, occupation, education, marital status, and family size). The research centers are located in the following communities: Ypsilanti and Inkster, MI; Boston, MA; Chicago, IL; Alameda and Contra Costa County, CA; Los Angeles, CA; Hackensack, NJ; and Pittsburgh, PA.