Population-based survey that aims to examine and characterize a population of older men and women in rural South Africa with respect to health, physical and cognitive function, aging, and well-being, in harmonization with other Health and Retirement Studies. The baseline survey was conducted among 5,059 men and women aged 40 years or older, who were sampled from within the existing framework of the Agincourt health and socio-demographic surveillance system (AHDSS), in rural Mpumalanga province, South Africa. Survey data were collected on cognitive and physical functioning, social networks, cardiometabolic disease and risk factors, HIV and HIV risk, and economic well-being. The survey also included anthropometric measures and point-of-care blood tests for hemoglobin, glucose and lipids. Dried bloodspots (DBS) were collected at the survey and later tested for HIV, HIV viral load, glucose and CRP. A sub-sample had more extensive laboratory follow-up testing, which will be available in future data releases. A second wave of the survey was administered in 2018 through 2019, and a third wave of the survey was administered in 2021 through 2022. Demographic information includes age, sex, income, education, marital status, number of children, and employment.