Contains 882 unique occurrences of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) extracted from 217 reports published between October 2012 and February 2018. Occurrences of MERS-CoV among humans, mammals, and environmental sources were extracted and geopositioned to the highest resolution possible (up to 5x5km). Special attention was given to spillover events (i.e., humans becoming infected from mammals). Thus, MERS-CoV occurrences meeting the criteria for index or unspecified cases are assigned their own rows; alternatively, multiple mammal, import, or secondary cases are collapsed to one row in the dataset.