The National Wellbeing Survey (NWS) is an annual population-based cross-sectional survey of adults aged 18 to 64 in the United States first collected in 2021. Survey topics include psychosocial wellbeing, social relationships and support, participation in social activities, physical health, mental health, health behaviors, health care use, employment quality and experiences, COVID-19 experiences, socioeconomic measures, political orientation, and demographic measures.