The Hispanic Established Populations for Epidemiologic Studies of the Elderly (EPESE) Frailty Study sought to apply a standard definition of frailty in a well-defined sample of Mexican American older adults and to examine the impact of frailty on disability, health related quality of life, institutionalization, and mortality in this population over time. This project is a continuation of a prior study (the Hispanic EPESE) examining the enabling-disabling process in this same population of aging Mexican Americans; data were collected from 1,031 older adults who were participating in the Hispanic EPESE. Only subjects who were physically capable of safely completing the muscle strength measures were included. Baseline interviews were collected for this subsample in 2006/2007 during Wave 6 of the Hispanic EPESE study. This collection includes data about respondents' health status, activities of daily living and their ability to perform tasks. Two-year follow-up data were collected in 2008/2009 from 731 participants in Wave 1. Demographic and background information include age, relationship status, gender, marital status and household composition. Follow-up waves of the baseline Hispanic EPESE provided cross-sectional and longitudinal examinations of the predictors of mortality changes in health outcomes, institutionalization and other changes in living arrangements, as well as changes in life situations and quality of life issues. Beginning with Wave 5, an additional sample of Mexican Americans aged 75 and over was included. The individuals included in this sample had higher average-levels of education than those of the surviving cohort.